作者@article {Leimane584 = {Leimane,诉和博士avniece, G. and Riekstina, V. and Sture, I. and Kammerer, S. and Chen, M.P. and Skenders, G. and Holtz, T.H.}, title = {Treatment outcome of multidrug/extensively drug-resistant tuberculosis in Latvia, 2000{\textendash}2004}, volume = {36}, number = {3}, pages = {584--593}, year = {2010}, doi = {10.1183/09031936.00003710}, publisher = {European Respiratory Society}, abstract = {In the present study, we characterised drug-resistance patterns, compared treatment outcome between extensively and nonextensively drug-resistant tuberculosis (non-XDR-TB) cases, and assessed risk factors for poor outcome in a high-prevalence country that screens all TB patients for first-line anti-TB drug resistance. We reviewed drug susceptibility test results among all pulmonary TB cases in Latvia diagnosed from 2000{\textendash}2004, as well as demographic and clinical characteristics, drug-resistance patterns, and treatment outcomes. During the 5-yr period, 1,027 multidrug-resistant tuberculosis (MDR-TB) cases initiated treatment. Among all cases, the proportion that experienced an outcome of cure or completion increased from 66.2 to 70.2\% (p = 0.06 for linear trend). Among the 48 (4.7\%) XDR-TB cases, 18 (38\%) were cured, four (8\%) died, three (6\%) defaulted, and treatment failed in 23 (48\%). In proportional-hazards analysis, characteristics significantly associated with poor outcome included XDR-TB, being retired, presence of bilateral cavitation, and previous MDR-TB treatment history for those aged >=55 yrs. Overall, treatment success among all MDR-TB cases increased over time. Strategies to prevent transmission of XDR-TB and to further improve treatment outcome are crucial for the future of TB control in Latvia.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/36/3/584}, eprint = {//www.qdcxjkg.com/content/36/3/584.full.pdf}, journal = {European Respiratory Journal} }