PT-杂志文章Au- Stewart，Ag au -Waterhouse，JC Au -Howard，PI -PTI-心血管自主神经功能在患有低氧慢性阻塞性肺部疾病DP的患者中-4 IP -10 4099 -http：//www.qdcxjkg.com/content/4/4/10/1207.short 4100 -http：//www.qdcxjkg.com/content.com/content/4/4/10/10/1207.full so -eur so -eur so -urRespir J1991 11月1日;4 AB-内部低氧血症被认为是糖尿病神经病中的致病机制。慢性阻塞性肺疾病（COPD）可能会发生类似的病理生理过程。在COPD中未识别自主神经病。我们将96例低氧COPD患者与22名年龄匹配的对照受试者进行了比较，以查看COPD中是否发生了自主功能障碍，以及是否与低氧血症的严重程度有任何相关性。心血管自主神经测试包括对Valsalva操纵的心率反应（主要是副交感神经功能），深呼吸和姿势变化和血压反应（主要是交感性起源）对姿势变化和持续的手夹。根据正常范围，早期的自主神经病被定义为一种异常检验和确定的自主神经病作为两个异常测试。这些自主神经测试在我们的研究人群中可再现。 Although the symptoms and signs of autonomic neuropathy were rare, definite autonomic dysfunction was found in 35%, and early autonomic neuropathy in a further 47%, of patients whose arterial oxygen tension (PaO2) was less than 8 kPa (60 mmHg). Only 18% of the control group had evidence of an age-related early autonomic dysfunction. Parasympathetic autonomic dysfunction was significantly correlated with PaO2 whilst the sympathetic tests were relatively normal. Correction of hypoxaemia for one hour or administration of ipratropium bromide or terbutaline had no effect on autonomic function. Subclinical autonomic neuropathy is a feature of hypoxaemic COPD. Its importance in the disease process and its role in prognosis needs evaluation.