TY -的T1 -淋巴细胞巨噬细胞相互作用:peripolesis of human alveolar macrophages JF - European Respiratory Journal JO - Eur Respir J SP - 59 LP - 66 VL - 5 IS - 1 AU - Lyons, DJ AU - Gautam, A AU - Clark, J AU - Harries, MG AU - Mitchell, EB AU - Milledge, JS AU - Balfour, BM Y1 - 1992/01/01 UR - //www.qdcxjkg.com/content/5/1/59.abstract N2 - Peripolesis is a phenomenon in which a lymphocyte attaches itself to another cell, usually a macrophage or veiled cell, and proceeds to circle around it. In emperipolesis, a related phenomenon, the lymphocyte invaginates the target cell so deeply that it appears to be intracytoplasmic. Lung cells in bronchoalveolar lavage fluids from 20 patients were observed in the living state and filmed. Peripolesis of the alveolar macrophages was recorded in six cases. These patients included one case each of carcinoma of the bronchus, tuberculosis, sarcoidosis and asthma, while two patients had no detectable lung disease. Five out of the six positive cases were females. In every instance there was a high number of lymphocytes in the washing. The peripolesed macrophages were not injured, but temporary alteration of the cell membrane was noted in a minority of film sequences. The peripolesing cells were also examined by transmission and scanning electron microscopy. The lymphocyte was found to be closely attached to the surface of the macrophage, with no invagination and its ultrastructure was that of a small lymphocyte. Peripolesis is probably a physiological mechanism concerned with regulation of the immune response in the lung. ER -