TY -的T1 Hyperosmolarity-induced增加气道反应及后期哮喘反应JF -欧洲呼吸杂志》乔和J SP - 290 LP - 295欧元六世- 4 - 3盟Bussieres年代盟——Turcotte H盟——BouletN2 -用超声雾化高渗生理盐水(UNHS)支气管刺激前后，观察吸入甲胆碱的气道反应性，发现这些变化与晚期哮喘反应(LAR)的发生有关。16名轻度至中度哮喘受试者在UNHS累积剂量刺激前和之后分别进行了两次连续的甲胆碱刺激。其中12名受试者也进行了单剂量高渗挑战，以记录LAR的发生，并确定UNHS是否有显著的累积剂量效应。如果观察到LAR，则在无挑战的对照日完成研究。在2个基线甲基胆碱刺激浓度下，一秒钟内强迫呼气量(PC20)下降20%(均值+/- SEM)分别为1.11 +/- 0.94和1.16 +/- 0.94 mg.ml.1时，对甲基胆碱的反应类似(r: 0.98)。然而，吸入PC20(均值+/- SEM)为0.57 +/- 1.00 mg.ml.1的UNHS后，其浓度显著升高(p < 0.001)。两名受试者在高渗刺激后1秒内用力呼气量(FEV1)下降到19和46%。 In this last subject, the LAR, not reproduced on the control day, was associated with a marked post-UNHS change in PC20, going from a baseline of 4.4 to 0.7 mg.ml.1 after UNHS. The % fall in FEV1 following the dose-response hyperosmolar challenge and the single-dose hyperosmolar challenge were not different, with mean values +/- SEM of 34.9 +/- 2.2 and 35.8 +/- 4.1, respectively, (p greater than 0.5). In conclusion, airway responsiveness to methacholine may increase following hyperosmolar saline inhalation, often unrelated to LAR. ER -