PT -期刊文章盟Martinez-Lopez马AU -Gomez-Cerezo, G AU - Villasante, C AU - Molina, F AU - Diaz, S AU - Cobo, J AU - Medrano, C TI - Pulmonary alveolar proteinosis: prolonged spontaneous remission in two patients DP - 1991 Mar 01 TA - European Respiratory Journal PG - 377--379 VI - 4 IP - 3 4099 - //www.qdcxjkg.com/content/4/3/377.short 4100 - //www.qdcxjkg.com/content/4/3/377.full SO - Eur Respir J1991 Mar 01; 4 AB - Pulmonary alveolar proteinosis is a rare idiopathic diffuse airspace disease characterized by intra-alveolar accumulation of large quantities of lipoproteinaceous material, with preservation of the lung interstitium. The clinical course of pulmonary alveolar proteinosis is variable. Spontaneous resolution is known to occur in up to a quarter of the cases. We describe two patients with untreated pulmonary alveolar proteinosis who experienced complete clinical, functional and radiographic resolution. In follow-up periods of fourteen and six years, both patients have remained asymptomatic.