TY - JOUR T1 -通气对象一氧化碳转移和肺容积的测量JF -欧洲呼吸杂志JO - Eur Respir J SP - 231 LP - 236 VL - 6 IS - 2 AU - Macnaughton, PD AU - Morgan, CJ AU - Denison, DM AU - Evans，TW Y1 - 1993/02/01 UR - //www.qdcxjkg.com/content/6/2/231.abstract N2 -在9名接受间歇性正压通气(IPPV)的健康志愿者中评估了通过再呼吸技术测量肺容量和一氧化碳转移因子(TLCO)的简单方法。将IPPV中三种吸入氧浓度(21、35和70%)下的TLCO、肺泡体积(VA)和一氧化碳转移系数(KCO)的测量结果与自主呼吸时的测量结果进行比较。我们还研究了10 cmH2O呼气末正压(PEEP)的影响。推导了肺泡毛细血管容积(Vc)和肺泡毛细血管膜扩散能力(Dm)。IPPV期间TLCO测量(TLCOIPPV)与自主呼吸(TLCOSV)密切相关(r = 0.92)。通气TLCO为自发呼吸TLCO的64 +/- 8%。KCO的通气和自主呼吸测量值之间有密切的一致性(r = 0.95;平均差0.14,95%范围一致+0.37 ~ -0.09 mmol。min-1 x kPa-1 x l-1)。自主呼吸时Vc为92 +/- 23 ml, IPPV时Vc为72 +/- 21 ml (p < 0.05). PEEP of 10 cmH2O significantly increased functional residual capacity (2.3 +/- 0.5 to 3.5 +/- 0.6 l) and decreased TLCO (5.9 +/- 1.0 to 5.3 +/- 1.2 mmol.min-1 x kPa-1), KCO (1.7 +/- 0.2 to 1.1 +/- 0.3 mmol.min-1 x kPa-1 x l-1) and Vc (82 +/- 22 to 56 +/- 20 ml). Dm did not change with PEEP. This simple method may be a useful means of assessing gas exchange and lung volume in ventilated subjects. It showed that PEEP increased lung volume but reduced TLCO and that this reduction appeared to be due to a reduction in capillary blood volume. ER -