TY -的T1 -急性暴露于猪灰尘引起支气管高反应性在健康受试者JF -欧洲呼吸杂志》乔和J SP - 400 LP - 404欧元六世- 6 - 3盟只是P AU -拉尔森,K Y1 - 1993/03/01 UR - //www.qdcxjkg.com/content/6/3/400.abstract N2 - 6城市主题,与很少或没有经验的农活儿,暴露在灰尘而重猪2 - 5 h。三个学科经历了有毒的症状4 - 5 h后接触的开始。支气管反应增加6 h内的所有对象(超过三个翻番的步骤不同醋甲胆碱测试)。一周后,气道反应部分规范化。The mean (interquartile range) cumulative dose of methacholine causing a 20% decrease in forced expiratory volume in one second (FEV1) was 3.1 (1.0-6.6) mg, before exposure, fell to 0.13 (0.01-0.76) mg 6 h after exposure (p < 0.02), and was 0.99 (0.42-1.5) mg one week later (n = 5, p < 0.05), Mean (SD) FEV1 decreased 5 (2)%. The concentration of total dust varied between 9 and 14 mg.m-3 and of endotoxin between 0.1 and 0.5 mu g.m-3. Thus inhalation of swine farm dust, caused a marked increase in bronchial responsiveness in non-sensitized subjects. ER -