TY -的T1 -病人的医疗管理with cystic fibrosis following heart-lung transplantation JF - European Respiratory Journal JO - Eur Respir J SP - 965 LP - 970 VL - 6 IS - 7 AU - Madden, BP AU - Kamalvand, K AU - Chan, CM AU - Khaghani, A AU - Hodson, ME AU - Yacoub, M Y1 - 1993/07/01 UR - //www.qdcxjkg.com/content/6/7/965.abstract N2 - Transplantation for end-stage respiratory failure in cystic fibrosis (CF), with encouraging medium-term results, is now possible. This paper details the postoperative medical treatment required by these patients. The management of 79 patients who underwent heart-lung transplantation is described. Details of intensive care, postoperative care, long-term follow-up, and the problems specific for cystic fibrosis patients are reported. The duration of care in the Intensive Care Unit (ICU) was 1-93 days (median 5 days). Intubation was required for 7 h to 93 days (median 48 h), and 11 patients required haemodiafiltration. High doses of cyclosporin A (mean 22 mg.kg-1 q.d.) were required. Acute rejection was common. There were 133 episodes of infection: bacterial 115, viral 11, and other organisms 7. Grand mal seizures occurred in 10 patients, lymphoproliferative disorders in 4, and obliterative bronchiolitis in 17. The median duration of hospital stay was 32 days. Despite having a multi-system disease, patients with CF can be successfully transplanted, if detailed attention is paid to their complex medical management. ER -