TY -的T1 Pentoxifylline不防止氧肺损伤大鼠JF -欧洲呼吸杂志》乔和J SP - 1397 LP - 1402欧元六世- 7 - 8盟Naureckas等非盟-因子,P盟——Benjaminov O盟,Hoffer E AU -南·V盟——Sznajder霁Y1 - 1994/08/01 UR - //www.qdcxjkg.com/content/7/8/1397.abstract N2 -氧过多已广泛用于急性肺损伤的模型。药物pentoxifylline已被证明在其他模型的肺损伤的保护作用。我们试图确定pentoxifylline防止氧肺损伤大鼠通过减少中性粒细胞在肺的积累。总共84只老鼠进行了研究。二十四老鼠被随机分为四组。Two groups of rats were pretreated for 48 h with either pentoxifylline (20 mg.kg-1) or saline, and then exposed to > 95% O2 for 60 h while treatments continued. Two groups of control rats received the same treatment regimens as the O2-exposed animals, but breathed room air. Neutrophil accumulation in the lung was quantified both by histology and myeloperoxidase activity. Lung neutrophil accumulation increased in the oxygen-exposed group receiving pentoxifylline as compared to oxygen- or air-exposed rats receiving saline injections. Total glutathione was higher in lung homogenates from the hyperoxic, pentoxifylline-treated group than in homogenates from the other three groups. To study survival, 60 rats were exposed to > 95% O2 for 120 h, 30 rats were pretreated with pentoxifylline, and 30 received saline. Survival after 120 h of exposure to hyperoxia was not altered by pentoxifylline treatment (pentoxifylline treated: 6 out of 30 survived; saline treated: 2 out of 30 survived). We conclude that pentoxifylline does not reduce mortality or lung injury in rats exposed to hyperoxia and is associated with an increase in lung neutrophil accumulation. ER -