PT - JOURNAL ARTICLE AU - naurecas, ET AU - Factor, P AU - Benjaminov, O AU - Hoffer, E AU - Sriram, V AU - Sznajder，霁TI - Pentoxifylline不防止氧肺损伤大鼠DP - 1994年8月01 TA -欧洲呼吸杂志》第六PG - 1397 - 1402 - 7 IP - 8 4099 - //www.qdcxjkg.com/content/7/8/1397.short 4100 - //www.qdcxjkg.com/content/7/8/1397.full所以欧元和J1994 8月01;7 AB -高氧已被广泛用于急性肺损伤模型。己酮可可碱已被证明对其他肺损伤模型有保护作用。我们试图确定戊氧基茶碱是否通过减少肺内中性粒细胞的积累来保护大鼠免受高氧肺损伤。实验共84只大鼠。24只大鼠随机分为4组。两组大鼠分别用己酮茶碱(20 mg.kg-1)或生理盐水预处理48 h，然后暴露于>95%氧气60小时，继续治疗。两组对照组的大鼠接受与接触o2的大鼠相同的治疗方案，但呼吸室内空气。 Neutrophil accumulation in the lung was quantified both by histology and myeloperoxidase activity. Lung neutrophil accumulation increased in the oxygen-exposed group receiving pentoxifylline as compared to oxygen- or air-exposed rats receiving saline injections. Total glutathione was higher in lung homogenates from the hyperoxic, pentoxifylline-treated group than in homogenates from the other three groups. To study survival, 60 rats were exposed to > 95% O2 for 120 h, 30 rats were pretreated with pentoxifylline, and 30 received saline. Survival after 120 h of exposure to hyperoxia was not altered by pentoxifylline treatment (pentoxifylline treated: 6 out of 30 survived; saline treated: 2 out of 30 survived). We conclude that pentoxifylline does not reduce mortality or lung injury in rats exposed to hyperoxia and is associated with an increase in lung neutrophil accumulation.