TY - T1的运动能力的因子分析,呼吸困难评级和COPD患者肺功能严重JF -欧洲呼吸杂志》乔欧元和J SP - 725 LP - 729 - 10.1183 / 09031936.94.07040725六世- 7 - 4盟再保险韦格纳AU - RA Jorres盟DK柯尔斯顿盟- H Magnussen Y1 - 1994/04/01 UR - //www.qdcxjkg.com/content/7/4/725.abstract N2 -在这项研究中我们旨在确定运动能力之间的关系,临床评价患者的呼吸困难和肺功能参数的严重慢性阻塞性肺疾病(COPD)通过因子分析的统计方法。Sixty two patients (mean age +/- SD, 66 +/- 9 yrs) in stable clinical condition, with a forced expiratory volume in one second (FEV1) < 65% of predicted were investigated. Before the study, therapy was optimized, including inhaled bronchodilators, theophylline and steroids. Exercise capacity was determined from the best 6 min walking distance achieved in five self-paced treadmill walks performed on consecutive days. Lung function testing comprised spirometry and body plethysmography. Four different tools were chosen to rate dyspnoea and quality of life: the Baseline Dyspnoea Index (BDI), the Oxygen Cost Diagram (OCD), a modified Medical Research Council (MRC) Scale, and the Chronic Respiratory Disease Questionnaire (CRQ). Principal component factor analysis revealed that the data could be reduced to three hypothetical underlying variables (factors), which accounted for 79% of the total variance. BDI, MRC, OCD, CRQ and walking distance were attributed to the first factor, forced expiratory volume in one second and airway resistance to the second factor, and lung volumes to the third factor. Thus, our data suggest that the pathophysiological condition of severe COPD is characterized by three statistically independent entities: 1) exercise capacity, dyspnoea and quality of life ratings; 2) airway obstruction; and 3) pulmonary hyperinflation.(ABSTRACT TRUNCATED AT 250 WORDS) ER -