RT Journal第SR电子T1痰液中石棉尸体的相关性JF欧洲呼吸杂志Jo Eur Respir J FD欧洲呼吸学会SP 680 OP 686 VO 9是4 A1 Teschler，H A1 Thompson，AB A1 Dollenkamp，R 188bet官网地址A1 KONIETZKO，N A1 KONIETZKO，N A1 COSTZKO，UR 1996 UL //www.qdcxjkg.com/content/9/4/680.Abstract Ab在具有职业石棉暴露的个人痰标本中存在石棉体（ABS）的存在已被充分记录。本研究的目的是与支气管肺泡灌洗（BAL）和肺组织的AB浓度相比，确定它们的临床相关性。在ABS的石棉历史（n = 93）或BAL流体分析阳性的良好文档暴露之后包括受试者（n = 42）。具有良好的AB暴露历史历史的受试者分为三组：重（第1组，N = 29）;中度（第2组，N = 31）;或偶尔接触（第3组，n = 33）。来自21个受试者的所有受试者和肺组织可获得BAL流体。为了评估可变性，10天，7,14,30和90天收集了后续痰收集的10个痰阳性受试者。通过膜过滤后的光学显微镜测定ABS。第1组（2.4 +/- 5.5 Ab.ML-1）中的平均痰AB含量最高，第2组（0.2 +/- 0.3 Ab.ML-1），3组中最低（0.1 +/- 0.1AB.ML-1）表明与累积暴露的相关性。 However, many negative sputum samples were noted, when BAL specimens were positive. The AB content of sputum and BAL specimens did not correlate. ABs were found in sputum of all subjects with a tissue content of > 1,000 AB-cm-3, but in none with contents of < 1,000 AB-cm-3. Substantial variability of ABs was found in the five sequentially collected sputa of 10 initially positive patients (coefficient of variation 28-93%), but only two false negatives were found in these 50 samples. Thus, sputum analysis for asbestos bodies is an insensitive method for assessing the lung asbestos burden, much less sensitive than bronchoalveolar lavage fluid analysis. However, a sputum sample positive for asbestos bodies is suggestive of a high lung asbestos burden.