@Article {Kormann1385，作者= {Kormann，Michael S.D.还有赫克托（Hector），安德烈亚斯（Andreas）和马科斯（Marcos），维罗妮卡（Veronica）和梅斯（Mays），劳伦·E（Lauren E.以及Moepps，Barbara和Griese，Matthias和Hartl，Dominik}，title = {CxCR1和CXCR2单倍型协同调节囊性纤维化肺病}，体积= {39}，数字= {6}，number = {6}，pages = {1385----1390}，，---1390}，， - ---1390}，，，---1390}，， - ---1390}，，， - ---1390}，，，---1390}，，，地位=年= {2012}，doi = {10.1183/09031936.00130011}，出版商= {欧洲呼吸社会}，摘要= {188bet官网地址囊性纤维化（CF）肺部疾病严重程度在很大程度上独立于CF跨膜电导剂（CFTR）贡献，指示贡献贡献的贡献遗传修饰符。趋化因子受体CXCR1和CXCR2在CF肺部疾病的发病机理中起着重要作用。在这里，我们确定CXCR1和CXCR2的遗传变异是否会影响CF肺部疾病严重程度。使用单核苷酸多态性（SNP）标记方法分析了德国CF患者（n = 442）的CF患者的基因组DNA（n = 442）。评估了CXCR1和CXCR2 SNP以及单倍型与CF肺部疾病严重程度，CXCR1和CXCR2表达以及中性粒细胞效应子功能的关联。CXCR1中的四个SNP和CXCR2中的三个SNP与CF患者的年龄调整后的肺功能密切相关。 SNPs comprising haplotypes CXCR1_Ha and CXCR2_Ha were in high linkage disequilibrium and patients heterozygous for the CXCR1-2 haplotype cluster (CXCR1-2_Ha) had lower lung function compared with patients with homozygous wild-type alleles (forced expiratory volume in 1 s <=70\% predicted, OR 7.24; p=2.30{\texttimes}10-5). CF patients carrying CXCR1-2_Ha showed decreased CXCR1 combined with increased CXCR2 mRNA and protein expression, and displayed disturbed antibacterial effector functions. CXCR1 and CXCR2 genotypes modulate lung function and antibacterial host defence in CF lung disease.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/39/6/1385}, eprint = {//www.qdcxjkg.com/content/39/6/1385.full.pdf}, journal = {European Respiratory Journal} }