TY - JOUR T1 -鼻腔持续气道正压:影响数字量脉冲在阻塞性睡眠呼吸暂停患者JF -欧洲呼吸杂志》乔和J SP - 1127 LP - 1135欧元——10.1183/09031936.00052611六世- 39 - 5盟Scholze亚历山德拉AU - Lamwers,斯蒂芬妮盟——Tepel马丁AU -塞纳,N2 -阻塞性睡眠呼吸暂停(OSA)与心血管风险增加有关。可通过鼻持续气道正压通气(nCPAP)治疗降低这种风险。由于阻塞性睡眠呼吸暂停与多种血管收缩因子增加有关，我们研究了nCPAP是否影响数字容积脉搏波。我们对94名连续接受多导睡眠描记术的患者和29名接受nCPAP治疗的患者在夜间睡眠时进行了数字光容积描记术。数字体积脉冲波是独立于研究者获得的，并使用一种连续自动分析算法进行量化。阻塞性睡眠呼吸暂停/低呼吸指数(AHI)为>10事件·h−1的患者，在夜间观察到显著的血管收缩(弗里德曼试验p<0.0001)。血管收缩与AHI呈显著正相关(Spearman相关，r=0.27;术中,0.01; n=94) and the arousal index (Spearman correlation, r=0.21; p<0.05; n=94). After 6 months of nCPAP treatment, the AHI was significantly reduced from 27±3 events·h−1 to 4±2 events·h−1 (each n=29; p<0.001) and vasoconstriction during the night was significantly reduced from 10±3% to 3±1% (p<0.01). We show changes in the reflective index during the night consistent with vasoconstriction in patients with OSA, which are significantly reduced after 6 months of nCPAP treatment. ER -