Background. Morbidity and mortality for critically ill patients with infections remains a global
healthcare problem. We aimed to determine whether β-lactam antibiotic dosing in critically ill …

Purpose Premorbid conditions affect prognosis of acutely-ill aged patients. Several lines of
evidence suggest geriatric syndromes need to be assessed but little is known on their relative …

Objectives We utilized the database of the Defining Antibiotic Levels in Intensive care unit
patients (DALI) study to statistically compare the pharmacokinetic/pharmacodynamic and …

Purpose To document and analyse the decision to withhold or withdraw life-sustaining treatment
(LST) in a population of very old patients admitted to the ICU. Methods This prospective …

Frailty is a valuable predictor for outcome in elderly ICU patients, and has been suggested to
be used in various decision-making processes prior to and during an ICU admission. There …

Lactate is an established prognosticator in critical care. However, there still is insufficient
evidence about its role in predicting outcome in COVID-19. This is of particular concern in older …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the coronavirus that
causes COVID-19, uses the membrane-bound form of the aminopeptidase angiotensin-converting …

Background We aimed to evaluate differences in outcome between patients admitted to
intensive care unit (ICU) after elective versus acute surgery in a multinational cohort of very old …

… Schefold, Georg Wolff, Malte Kelm, Michael Beil, Sviri Sigal, Peter Vernon van Heerden,
Wojciech Szczeklik, Miroslaw Czuczwar, Muhammed Elhadi, Michael Joannidis, Sandra …

OBJECTIVES To develop a scoring system model that predicts mortality within 30 days of
admission of patients older than 80 years admitted to intensive care units (ICUs). DESIGN …