文摘
药对病人使用干粉吸入器,如Turbuhaler,被认为是影响吸气流动使用。临床研究表明,该输送系统可以有效地使用。然而,尚不清楚如何总weight-corrected剂量交付给航空公司因年龄而异。沉积研究使用锝99 m (99 mtc)贴上布地奈德为了确定执行货到年龄的影响。20一个孩子与囊性纤维化,4-16年岁被招募。他们是临床稳定与正常肺功能。最初,γ相机扫描被洪水前的源包含37个兆贝可99矿渣mtc。随后,受试者通过低阻吸入吸入过滤器连接到一个商用Turbuhaler。后来立即从非商业Turbuhaler包含布地奈德吸入贴上99矿渣mtc,然后接受前部和后部γ相机扫描。Turbuhaler吸入器都是连接到一个便携式肺活量计和吸气流量通过Turbuhaler峰值为每个吸入被记录。 The total body dose was calculated from the dose deposited on the inspiratory filter connected to the commercial Turbuhaler. Analysis of the gamma camera images provided information on the proportion of the radiolabel delivered to the lungs compared to that deposited in the upper airway and stomach. As expected, a highly significant positive correlation was noted between the peak inspiratory flow generated by the patient through the Turbuhaler and the dose delivered to the lung. Similarly, there was a highly significant positive correlation between age and "total lung dose". However, when total lung dose was corrected for body weight, there was a nonsignificant negative correlation with age. This study suggests that the "weight-corrected lung dose" achieved when children aged > 6 yrs use the Turbuhaler, is largely independent of age. It would appear that the flow-dependent properties of this device are such that the reduced peak inspiratory flow generated by younger children results in a lower dose to the lungs, but that this is off-set by their lower body weight. This is unlikely to be a property of other devices with different flow/drug delivery characteristics.