摘要

背景:严重慢性阻塞性肺疾病(COPD)患者在生活质量的大部分方面存在损害，但动脉血氧分压(PaO2)损害与生活质量之间的关系尚未确定。以前的研究使用了一般的健康措施，如疾病影响概况(SIP)。在这项研究中，一项针对特定疾病的健康测量，即圣乔治呼吸问卷(SGRQ)，被用来检查两者之间的关系。方法:对41例中位年龄71岁(47-85岁)的COPD患者(20名男性)进行评估。测量1秒用力呼气量(FEV1)、PaO2和动脉血二氧化碳分压(PaCO2)，并完成SGRQ、SIP和医院焦虑抑郁量表(HAD)。结果:平均(SD)值为:FEV1, 0.83(0.29)升;PaO2, 7.49 (1.03) kPa;PaCO2, 6.30 (1.05) kPa;SGRQ总分55.3分(18.2分);SIP总分15.4分(9.2分); anxiety score, 5.7 (4.3); depression score, 5.3 (3.4). PaO2 was significantly correlated with the SGRQ total scores but not with the SIP total score. The SGRQ total score also correlated with anxiety and depression. Multivariate analysis showed that depression score and PaO2 were both significant covariates of the SGRQ total score. CONCLUSIONS: These findings suggest that, in patients with severe COPD, quality of life is related to the severity of hypoxaemia, but this relationship is only detectable when using a disease-specific health measure.