摘要

背景:吸烟可引起气道炎症和肺功能损害。为了确定气道炎症的类型和程度与肺功能下降之间的关系，对吸烟者和戒烟者的痰中白细胞进行了检测。方法:46名中位年龄64岁的吸烟者和戒烟者(25%;在15年的随访期结束时，对吸烟史为40.1(31.7;53)包年的75%的62;66)人进行了肺功能测试和问卷调查。通过吸入高渗盐水诱导痰，并对细胞旋液制剂进行白细胞计数。结果:38名受试者(78%)获得了足够的痰样本。1秒用力呼气量(FEV1)与肺活量(VC)之比为67.1 (60;72)%， FEV1年下降19.4 (12;30)ml/年。气道梗阻(FEV1/VC < 63%)患者的中性粒细胞数量(77(50;86)%)高于无气道梗阻的患者(60(43;73)%)。慢性咳痰患者的中性粒细胞百分比(77(62;85)%)也明显高于无咳痰患者的中性粒细胞百分比(57(45;75)%)。 Increased levels of neutrophils in the sputum were correlated with a rapid decline in FEV1 over the 15 year follow up period. CONCLUSIONS: Airways obstruction and chronic expectoration, as well as accelerated decline in lung function, are associated with increased numbers of neutrophils in the sputum of smokers and ex-smokers which suggests that neutrophilic inflammation of the airways may be involved in the pathogenesis of chronic obstructive pulmonary disease.